Luteolina 100mg 30 cápsulas

DESCRIÇÃO:

A luteolina é um flavonoide encontrado no amendoim e em diferentes espécies vegetais, tais como salsa, alcachofra, manjericão e aipo, onde auxilia na proteção contra insetos, microrganismos e radiação ultravioleta. No organismo humano, a luteolina promove a inibição de enzimas e fatores de transcrição que contribuem para a síntese de mediadores inflamatórios, bem como aumenta a transcrição de diferentes compostos antioxidantes. Desta forma, inúmeras evidências apontam que a luteolina atua como um agente neuroprotetor, auxiliando na redução dos prejuízos cognitivos associados a doenças neurodegenerativas e ao processo de envelhecimento, além de promover ação cardioprotetora e auxiliar no tratamento do câncer.

INDICAÇÃO:

Melhora função cognitiva;

Ação neuro e cardioprotetora;

Propriedade antioxidante

COMPOSIÇÃO:

Luteolina       100mg

Excipiente qsp 100mg

MODO DE USO:

Tomar 1 cápsula uma a duas vezes ao dia ou conforme orientação médica.

VALIDADE;

6 meses.

BIBLIOGRAFIA:

1. Nabavi SF, Braidy N, Gortzi O, et al. Luteolin as an anti-inflammatory and neuroprotective agent: A brief review. Brain Res Bull. 2015;119:1-11. doi:10.1016/j.brainresbull.2015.09.002

2. Imran M, Rauf A, Abu-Izneid T, et al. Luteolin, a flavonoid, as an anticancer agent: A review. Biomed Pharmacother. 2019;112(January). doi:10.1016/j.biopha.2019.108612

3. Ashaari Z, Hadjzadeh MAR, Hassanzadeh G, et al. The Flavone Luteolin Improves Central Nervous System Disorders by Different Mechanisms: A Review. J Mol Neurosci. 2018;65(4):491-506. doi:10.1007/s12031-018-1094-2

4. Theoharides TC, Stewart JM, Hatziagelaki E. Brain “fog,” inflammation a nd obesity: Key aspects of neuropsychiatric disorders improved by luteolin. Front Neurosci. 2015;9(JUN). doi:10.3389/ fnins.2015.00225

5. Dirscherl K, Karlstetter M, Ebert S, et al. Luteolin triggers global changes in the microglial transcriptome leading to a unique anti-inflammatory and neuroprotective phenotype. J Neuroinflammation. 2010;7:1-16. doi:10.1186/1742-2094-7-3

6. Jones MK, Nair A, Gupta M. Mast cells in neurodegenerative disease. Front Cell Neurosci. 2019;13(April):1-9. doi:10.3389/fncel.2019.00171

7. Wruck CJ, Claussen M, Fuhrmann G, et al. Luteolin protects rat PC 12 and C6 cells against MPP+ induced toxicity via an ERK dependent Keapl-Nrf2-ARE pathway. J Neural Transm Suppl. 2007;(72):57-67. doi:10.1007/978-3-211-73574-9_9

8. Aziz N, Kim MY, Cho JY. Anti-inflammatory effects of luteolin: A review of in vitro, in vivo, and in silico studies. J Ethnopharmacol. 2018;225(May):342-358. doi:10.1016/j.jep.2018.05.019

9. Luo Y, Shang P, Li D. Luteolin: A Flavonoid that has multiple cardio-protective effects and its molecular mechanisms. Front Pharmacol. 2017;8(OCT):1-10. doi:10.3389/fphar.2017.00692

10. Ou HC, Pandey S, Hung MY, et al. Luteolin: A natural flavonoid enhances the survival of HUVECs against oxidative stress by modulating AMPK/PKC pathway. Am J Chin Med. 2019;47(3):541- 557. doi:10.1142/S0192415X19500289

11. Wu G, Li J, Yue J, Zhang S, Yunusi K. Liposome encapsulated luteolin showed enhanced antitumor efficacy to colorectal carcinoma. Mol Med Rep. 2018;17(2):2456-2464. doi:10.3892/ mmr.2017.8185

12. Lin Y, Shi R, Wang X, Shen H-M. Luteolin, a Flavonoid with Potential for Cancer Prevention and Therapy. Curr Cancer Drug Targets. 2008;8(7):634-646. doi:10.2174/156800908786241050

13. Li X, Chen M, Lei X, et al. Luteolin inhibits angiogenesis by blocking Gas6/Axl signaling pathway. Int J Oncol. 2017;51(2):677-685. doi:10.3892/ijo.2017.4041

14. Taliou A, Zintzaras E, Lykouras L, Francis K. An open-label pilot study of a formulation containing the anti-inflammatory flavonoid luteolin and its effects on behavior in children with autism spectrum disorders. Clin Ther. 2013;35(5):592-602. doi:10.1016/j.clinthera.2013.04.006

15. Gelabert-Rebato M, Wiebe JC, Martin-Rincon M, et al. Enhancement of exercise performance by 48 hours, and 15-day supplementation with mangiferin and luteolin in men. Nutrients. 2019;11(2):1-24. doi:10.3390/nu11020344

16. Wang L, Lee IM, Zhang SM, Blumberg JB, Buring JE, Sesso HD. Dietary intake of selected flavonols, flavones, and flavonoid-rich foods and risk of cancer in middle-aged and older women. Am J Clin Nutr. 2009;89(3):905-912. doi:10.3945/ajcn.2008.26913

17. Gates MA, Tworoger SS, Hecht